About Amprion

Amprion is the global leader in advancing the diagnosis of neurodegenerative disorders through the development and application of seed amplification assays (SAA). Our technology empowers precision medicine by enabling early, accurate detection of misfolded proteins associated with diseases like Alzheimer’s, Parkinson’s, and Lewy body dementia.

Historically, diagnosis and treatment of neurodegenerative diseases have been symptom-driven, often resulting in misdiagnosis and delayed care. Many patients endure a “diagnostic odyssey”, seeking answers that are often not confirmed until autopsy. With limited tools available, physicians have historically had to rely on their best judgment rather than definitive biological evidence.

Amprion’s SAAmplify™ platform changes that paradigm. By enabling highly sensitive, early detection of disease-causing proteins, we provide critical biological insights that support earlier intervention, enhance clinical trial recruitment, and accelerate the discovery of disease-modifying therapies. Working at Amprion means contributing to our mission to facilitate the end of Alzheimer’s, Parkinson’s, and other neurodegenerative disorders through early diagnostic testing.

About the role

The Research Associate I/II is responsible for executing experiments that facilitate the development, optimization or modification, and validation of assays used in the research laboratory. May contribute to experimental design and data analysis.

We are seeking a motivated Research Associate with a strong background in biochemistry and hands-on experience in protein-related research. The ideal candidate will have completed a Master’s thesis focused on proteins—such as structure, folding, interactions, or enzymatic function—and be eager to contribute to cutting-edge projects in protein characterization and drug discovery

Responsibilities

• Design and conduct experiments involving protein expression, purification, and analysis
• Perform biochemical assays to study protein structure, activity, and interactions
• Collaborate with cross-functional teams in molecular biology, biophysics, and structural biology
• Analyze and interpret experimental data; contribute to internal reports and publications
• Maintain detailed laboratory records and adhere to safety and quality standards

Educational Experience:

M.Sc. in Biochemistry, Molecular Biology, Biophysics, Bioengineering, or a related field. Completion of a Master’s thesis focused on proteins (e.g., enzyme kinetics, protein-protein interactions, structural or functional studies) is preferred.

Job Related Experience:

The successful candidate will have 0-3+ years of experience working in assay development of chemistry or molecular based test platforms in a variety of biological matrices (i.e., CSF, skin, blood).

Proven experience with techniques such as ELISA, SDS-PAGE, Western blotting, chromatography (FPLC/HPLC), recombinant protein expression systems, and spectroscopic or calorimetric assays is preferred.

Must have strong analytical and problem-solving skills, in addition to excellent written, oral and collaboration skills. Must work well in a team environment.

Essential Job Duties and Responsibilities:

• Ensure adherence to laboratory safety and quality control procedures.

• Process biological specimens following the laboratory’s procedures for

specimen receipt, unpacking, handling and accessioning.

• Execute analytical experiments.

• Support transfer to laboratory operations using good laboratory practice.

• Assist with design, troubleshooting, optimization, and validation of assay

procedures, components and workflows.

• Support the research laboratory in the design and implementation

of appropriate assay controls.

• Maintain detailed and accurate laboratory notebooks, as applicable.

• Contribute expertise on instrumentation, data interpretation, and reporting.

• Participate in and/or facilitate specimen transport, organization and storage.

• Participate in and/or facilitate reagent and supply inventory management.

• Work closely with cross-functional teams and participate in/contribute to

meetings as required.

• May assist with equipment preventative maintenance and troubleshooting,

preparation and storage of reagents.

• May participate in internet research and manuscript preparation and review.

• Perform other job-related duties as assigned.

Work Environment:

Research laboratory and office space

Physical Requirements: for this job, the employee is regularly required to sit, talk, hear, operate equipment and a computer. The employee is occasionally required to stand, walk, and use hands and arms to lift and/or move up to 10 lbs. Specific vision abilities required by this job include close vision, and the ability to adjust focus.

In this work environment, the employee is occasionally exposed to moving mechanical parts, unpleasant odors, and loud noises. Interaction with laboratory equipment, samples, supplies and laboratory personnel may be required whereby appropriate precautions are to be taken per the company’s Safety and Injury, Illness and Prevention Plans.

Compensation and Benefits:

• Base Salary Range: $65k-$85K
• Annual bonus potential
• Benefits: Comprehensive medical, dental, and vision coverage; 401(k) plan
• Equity Potential: Opportunity for stock options
• Additional: Professional development opportunities and the chance to be part of a pioneering organization advancing the future of neurodegenerative disease diagnosis.