Who are we?

Arbor Biotechnologies™, a next-generation gene editing company based in Cambridge, MA, is advancing a pipeline of novel gene editing therapeutics to address a wide range of genetic conditions – from the ultra-rare to the most common genetic diseases. The company’s unique suite of optimized gene editors goes beyond the limitations of early editing technologies to unlock access to new gene targets and has fueled a robust pipeline of first-in-class assets focused on diseases of high unmet need. With Arbor’s lead program, ABO-101 for the treatment of primary hyperoxaluria type 1, progressing into clinical trials, the company continues to focus their research and development efforts on genomic diseases of the liver and CNS for which there are no existing functional cures. For more information, please visit: arbor.bio.

Who are you?

Passionate, determined, and accountable. Curious, resourceful, innovative, forward thinking, and resilient. Authentic, humble, open-minded and puts team above self. At Arbor, our people embrace these qualities, so if this sounds like you then please read on!

About the Role:

We are seeking a highly skilled and motivated Principal Research Associate to join the Precision Editing Research team at our Cambridge site. The ideal candidate will develop and execute on a combination of traditional and high-throughput assays to determine and optimize in vitro parameters of our proprietary gene editors. Working closely with a dynamic and multidisciplinary team, the successful candidate will advance the state-of-the-art in protein characterization and engineering, while making contributions to develop our gene editing tools into therapies to treat human disease.

What you can expect:

• Independently design and execute on a suite of biochemical assays including but not limited to plate and gel-based enzymatic assays, binding experiments, and protein quantification techniques
• Develop and implement high throughput biochemical and enzymatic screens in 96, 384, or 1536-well formats to support arrayed screening campaigns and iterative protein engineering cycles
• Contribute to exploratory assay development to uncover mechanistic insights to advance our gene editing technologies
• Optimize and troubleshoot customized assays for protein quality control and activity evaluation to align with project team needs
• Work cross-functionally with other R&D teams including disease indication, lead identification, and in vivo pharmacology
• Accurately document, compile, and analyze experimental data using electronic lab notebooks
• Communicate and present results at departmental/project meetings and contribute to experimental planning, execution, and interpretation

What you Bring:

• Bachelor’s or Master’s degree in Biochemistry, Molecular Biology, Biotechnology, Biomedical Engineering, or a related field with 4-6 years of industry experience
• Proficiency in developing exploratory biochemical assays to evaluate enzyme activity and quantification, preferably in the context of nucleic acid-modifying or binding enzymes
• Hands-on experience with automated liquid handlers/dispensers (e.g. Echo, Bravo) and integrating them into existing experimental workflows
• Familiarity with next-generation sequencing workflows, including library preparation, and the ability to analyze NGS or other large experimental datasets
• Experience with mammalian cell-based experiments, including transient and stable transfection, to explore mechanistic hypotheses is a plus.
• Ability to thrive in a highly matrixed, interdisciplinary team environment, fostering collaboration and innovation

Our Values: 

Our values govern the work we do at Arbor, and we’re hoping that they resonate as strongly with you as they do with us!

· Purposeful Action: Start with The Why

· Bold Resilience: Adopt a Growth Mindset

· Humble Authenticity: Start in the Heart

We promote diversity and inclusion not just in our recruitment processes, but in everything we do. We’re an equal opportunity employer and we will continue to ensure our recruitment process is free of bias and our workplace is inclusive, positive, and free of discrimination and respecting of all backgrounds and beliefs.