Who are we?

Arbor Biotechnologies™, a next-generation gene editing company based in Cambridge, MA, is advancing a pipeline of novel gene editing therapeutics to address a wide range of genetic conditions – from the ultra-rare to the most common genetic diseases. The company’s unique suite of optimized gene editors goes beyond the limitations of early editing technologies to unlock access to new gene targets and has fueled a robust pipeline of first-in-class assets focused on diseases of high unmet need. With Arbor’s lead program, ABO-101 for the treatment of primary hyperoxaluria type 1, progressing into clinical trials, the company continues to focus their research and development efforts on genomic diseases of the liver and CNS for which there are no existing functional cures. For more information, please visit: arbor.bio.

Who are you?

Passionate, determined, and accountable. Curious, resourceful, innovative, forward thinking, and resilient. Authentic, humble, open-minded and puts team above self. At Arbor, our people embrace these qualities, so if this sounds like you then please read on!

About the Role: 

We are seeking a Research Associate / Senior Research Associate to join the Analytical Sciences team at our Cambridge site. The person will develop and execute molecular biology and biophysical methods for the testing of AAV- and LNP-based therapeutic CRISPR gene editing products in preclinical development through commercial production. Our mission is to translate developmental processes to commercial reality for patients through scientific expertise and engineering innovation. 

What You Can Expect:

• Develop and execute molecular biology and biophysical methods for the characterization of AAV- and LNP-based therapeutics including but not limited to AAV titer, capsid purity, particle size, encapsulation efficiency.
• Analyze AAV and LNP vectors in support IND-enabling pharmacology studies.
• Work collaboratively in cross-functional teams to transfer developed analytical assays to CROs for GMP testing.
• Maintain accurate and detailed documentation of experimental procedures and test results in lab notebook and document control systems.
• Assist with authoring, reviewing and editing experiment summaries and study reports.
• Independently identify and propose solutions and/or resolve routine technical problems.
• Communicate results at team meetings, contribute to project and experiment planning

What You Bring: 

• Bachelor’s or Master’s degree in Chemistry, Biochemistry, Molecular Biology, Biotechnology, or a related field.
• 3-5 years of experience working with AAV and/or LNP analytical development including hands on experience with analytical techniques such as UPLC, CE and ddPCR.
• Strong problem-solving skills and attention to detail.
• Ability to expresses oneself clearly and concisely; document issues and/or concerns concisely; timely and effectively communicates issues to supervisor.
• Knowledge of GMP and quality control requirements is a plus.

Our Values: 

Our values govern the work we do at Arbor, and we’re hoping that they resonate as strongly with you as they do with us!

· Purposeful Action: Start with The Why

· Bold Resilience: Adopt a Growth Mindset

· Humble Authenticity: Start in the Heart

We promote diversity and inclusion not just in our recruitment processes, but in everything we do. We’re an equal opportunity employer and we will continue to ensure our recruitment process is free of bias and our workplace is inclusive, positive, and free of discrimination and respecting of all backgrounds and beliefs.