Drug development shouldn’t be guesswork, not when patients are waiting.

Pathos is building a next-generation biotech with AI at the core. Not as a feature, but as the operating system for how medicines get developed. We believe most drugs don’t fail because the science was wrong. They fail because they were tested in the wrong patients, with the wrong assumptions, in trials that couldn’t answer the real question: who benefits, and why?

Pathos exists to change that. We’re building the largest foundation model in oncology and pairing it with proprietary AI systems, deep oncology expertise, and 200+ petabytes of multimodal data linked to patient outcomes, so we can make development decisions with more precision, much earlier. 

This is not theoretical. We’re well-capitalized and have the leadership to build a generational company. We invest in and advance our own clinical-stage programs, using our AI platform to sharpen trial design, patient selection and biomarker strategy. So therapies reach the patients most likely to benefit, sooner.

If you’re driven by purpose, energized by complexity, and want to apply AI, biology, or both to redefine the future drug development, come build Pathos with us.

About the Role

The Director/Senior Director of Biostatistics will take ownership of trial-level statistical design, analysis, and regulatory deliverables across our oncology programs. This role reports to the Vice President, Head of Clinical Development, and is ideal for a hands-on biostatistician who thrives on applying rigorous statistical methods to advance clinical development. You will partner closely with clinical, regulatory, and data science colleagues to design and analyze studies, support submissions, and ensure high-quality statistical contributions to key program decisions.

Key Responsibilities

• Lead statistical design and analysis for oncology clinical studies (Phases I–III).
• Develop and review statistical sections of protocols, SAPs, study reports, and regulatory documents.
• Execute and oversee interim and final analyses, ensuring high scientific rigor.
• Apply advanced statistical methodologies (e.g., survival analysis, Bayesian, adaptive designs).
• Collaborate with data management and programming teams to ensure data quality and analysis readiness.
• Support preparation of regulatory submissions and agency interactions (FDA, EMA, etc.).
• Serve as the statistical expert on cross-functional study teams.
• Contribute to developing tools, templates, and best practices for the growing biostatistics function.

What We’re Looking For

• PhD or MS in Biostatistics (or related field).
• 7–12 years of industry experience in biostatistics (oncology preferred).
• Hands-on expertise in clinical trial design, statistical analysis, and regulatory deliverables.
• Strong SAS/R programming skills.
• Demonstrated success with innovative trial methodologies (e.g., adaptive, Bayesian).
• Excellent communicator and collaborator across clinical, regulatory, and data teams.
• Thrives in a dynamic, fast-paced, environment.

Location

The preferred location for this position is our New York City headquarters, although exceptional remote candidates will also be considered.