About Halda Therapeutics

Halda Therapeutics is a New Haven CT based, venture-backed biotechnology company focused on the development of a proprietary RIPTAC™ (Regulated Induced Proximity TArgeting Chimeras) therapeutics that work by a novel “hold and kill” mechanism for the precision treatment of cancer. The novel mechanism of action of RIPTAC therapeutics is uniquely designed to address cancer’s ability to evolve bypass mechanisms of resistance, a common limitation of today’s precision oncology medicines.

Our lead RIPTAC programs are in development for major solid tumor types, prostate cancer and breast cancer, with additional RIPTAC therapeutic programs in our pipeline to treat unmet medical needs in cancer. The company initiated its Phase 1 trial in metastatic, castration-resistant prostate cancer (mCRPC) in Q1 of 2025. 

Halda, located in New Haven CT, was founded by Yale Professor Craig Crews and is led by a leadership team with deep expertise in bifunctional drug discovery, platform innovation, and company building. Halda has raised $200 million in total capital and is funded by top tier venture capital firms.

At Halda, our team is a collective force for drug innovation to conquer cancer.  Halda is a place where you can embrace your purpose and be your true self.  Learn more about us at www.haldatx.com.

The Position

We are seeking a highly motivated medicinal chemist to work with colleagues towards creating precision medicines for oncology. As a key member of the team, she/he will help lead Halda’s exploratory efforts, working in close concert with chemistry and biology team members in the design and discovery of RIPTACs aimed at new targets for patients with unmet medical need.

Key Responsibilities

• As a dynamic project leader, drive and direct medicinal chemistry functions for one or more exploratory drug discovery projects, working in with partners in molecular and cellular biology, pharmacology, computational chemistry, structural biology, and other key functions
• Analyze screening data, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies
• Provide scientific direction and leadership for synthetic and medicinal chemistry activities of external CRO FTEs
• Participate in portfolio and project reviews, lead the preparation and presentation of dossiers for nomination and compound portfolio advancement
• Participate in shaping and implementing strategies that support medicinal chemistry growth objectives
• Serve as a scientific expert in medicinal chemistry with both internal and external partners and provide recommendations regarding new targets and emerging external opportunities
• Ensure optimal interaction/communication and provide updates on project status to leadership

We are seeking candidates who are:

·         Skilled at communicating and collaborating in a multidisciplinary environment

·         Driven to learn and develop in a fast-paced biotech research setting as a member of an interdisciplinary research team

Qualifications

• Ph.D. in organic or medicinal chemistry, with 5-7 years industry experience. Or M.Sc. in organic or medicinal chemistry with >20 years industry experience
• Must have a strong knowledge of organic and medicinal chemistry
• The candidate must be able to work in a hybrid format, with the expectation to be on site at least 3 days a week
• Expertise in data analysis/interpretation and data management are essential
• Demonstrated ability to learn new techniques and solve complex problems
• Demonstrated oral and written communication skills, including visualization of data and drafting presentations
• Demonstrated experience in preparation of patent documents and driving intellectual property strategy
• Excellent written and verbal communication as well as interpersonal skills
• Individual must be self-motivated, well-organized, reliable and able to prioritize workload
• Driven to thrive in multifunctional role at a nimble, fast-paced biotech company

Compensation

The estimated salary range for this position is $140,000 to $175,000.  Actual compensation will be dependent on candidate experience and other factors.

The compensation will also include an annual bonus and equity.

Benefits

Halda offers a comprehensive and competitive benefit package, including subsidized medical, dental, vision, ST/LT disability, a 401k Plan with generous company contribution and free parking at our New Haven headquarters.  We also offer tuition reimbursement and paid parental leave.

If you are interested in this opportunity and meet the requirements, please submit your resume and cover letter for consideration.

Halda is an Equal Opportunity Employer.

Principals only.