At Pathos, we’re reimagining what’s possible in oncology drug development.

Founded by the team that built and scaled Tempus Labs, home to the world’s largest library of clinical and molecular data, Pathos is on a mission to revolutionize precision medicine in cancer. We’re using AI and machine learning not as buzzwords, but as fundamental tools to understand biology, identify precise disease drivers, and match patients to the therapies they truly need.

Our vision is bold: to create a new model for drug discovery and development, one rooted in deep data, integrated science, and rapid translation. We’re not building another pharma company, we’re building a platform to find better medicines, faster, and to get them to the right patients at the right time.

We’ve already begun assembling a portfolio of clinical-stage oncology assets, and we’re applying our technology to select the right indications, optimize clinical design, and increase the probability of success, from bench to bedside.

We believe that the current system moves too slowly, and too many patients are still waiting. That’s why we’re here. That’s why Pathos exists.

If you’re driven by purpose, excited by complexity, and eager to work alongside brilliant, kind, and mission-aligned teammates, we’d love to meet you.

We’re headquartered in New York City, with a distributed team across the U.S., and operate with the focus and agility of a startup while building with the scale and ambition of something much bigger.

Come help us build it.

About the role

The Medical Director/Senior Medical Director of Clinical Development will be a member of the Clinical Development Team, which is responsible for driving the clinical development strategy and execution.  You will have direct responsibility for the design, execution, oversight, and analysis of clinical trials. You will also collaborate with R&D, Translational Medicine, Biomarker, and other cross-functional teams to incorporate the appropriate biomarker studies into the protocol and to correlate clinical and translational findings to drive optimal clinical development. In addition, you will be providing medical and scientific expertise to cross-functional colleagues and play a critical role partnering with the cross-functional asset team to define clinical strategies. You will be reporting to the Head of Clinical Development.

Key Responsibilities

• Medical Monitoring
• Medical review of trial data, including reviewing eligibility data
• Clinical site interactions, including addressing medical questions and providing site education (including safety management), assessment of key safety-related serious adverse events, and approving safety narratives
• Drafting of clinical protocols, along with medical writing & colleagues from Clinical Operations, and providing the medical strategic oversight of protocol development, including study design, targeted patient populations, eligibility criteria, and defining safety risks & mitigation strategies
• Fulfilling GCP and compliance obligations for clinical conduct and maintaining all required training
• Contributing to the Clinical Strategy and Clinical Development Plans for the company’s asset(s)
• Providing oversight and medical accountability for the company’s clinical trials
• Identifying/ building relationships with principal investigators and KOLs on the treatment modality, indication, and novel clinical trial designs and biomedical statistical analyses
• Supporting the executional delivery of clinical studies (e.g., site activation, status of enrollment, adjudication for protocol violations, medical validation/ data clean-up, and as the medical resource for the site staff)
• Interacting with Health Authorities & IRBs/ECs as the Clinical Program Lead
• Drafting and authoring clinical content for CSRs, regulatory reports, briefing books, and submission documents to support closure, clinical narratives, reporting, and filing of the study in partnership with colleagues in clinical operations.
• Staying current on the clinical development and regulatory issues related to other competitive or relevant compounds in development and providing recommendations on changes needed to the strategy or clinical development plan if needed
• Maintaining a clinical and scientific reputation in the modalities and diseases pertinent to Pathos

Who you are

• MD is required (or a US-equivalent)
• Sub-specialty training in Medical Oncology (preferred)
• 5 or more years of Biotech/Pharma industry experience in Oncology Clinical Trial development and execution, preferably in solid tumors in Phase I/II/III
• Experience in the drug development process, delivering and executing on effective clinical trial plans and protocols
• Leadership and mentorship skills with a hands-on (working leader) approach are required
• Proven ability to lead teams, especially in a remote/virtual environment, and cross-functionally is very important
• Ability to travel up to 30% (domestic and international)