Vilya is a computational biotechnology company creating a novel class of medicines to precisely target disease biology. We believe computational approaches are an integral, if not foundational, component of drug discovery and development. 

We are harnessing the power of our platform to go after previously impossible targets in an array of indications. Vilya’s ultimate goal is to solve some of the most challenging unmet medical needs that exist today.

Our Vision: Harness a revolution in technology and biology to better human health.

Our Mission: Build an independent, leading biotech company founded on intelligent drug design to cure the incurable.

We are seeking a Scientist, Macrocycle Design to apply state-of-the-art de novo design methodologies to computationally discover, develop, and evaluate therapeutic macrocycles. As a member of the design team in Seattle WA, you will leverage your knowledge of cutting edge methods in protein design and peptide chemistry to augment Vilya’s existing design platform.

RESPONSIBILITIES: 

• Collaborate with multi-disciplinary teams in the discovery and development of macrocyclic molecules with potency, selectivity, and in vivo stability using structure-guided approaches.
• Apply individual de novo design methods and integrated pipelines that will generate macrocycles in support of programs.
• Analyze data from experimental and computational assays to improve methodology throughout Vilya’s therapeutic discovery platform.
• Innovate Vilya’s computational design platform by building state-of-art de novo design workflows

PREFERRED QUALIFICATIONS:

• Ph.D. in chemistry, biochemistry, computational biology or other closely related fields at the intersection of computation, medicinal chemistry and drug discovery. 
• Hands-on experience with state-of-the-art protein design tools applied to de novo design of macrocyclic peptides in conjunction with a deep understanding of macrocyclic peptide conformational analysis
• Extensive hands-on experience with parallel job execution and high performance computing systems
• Expertise in working with high-level programing languages such as Python
• Expertise in integrating computational models into scalable and reproducible workflows
• Experience in modern solid-phase peptide synthesis
• Adept at working in a multi-disciplinary team.

VILYA BENEFITS:

• Opportunity to work in a disruptive startup with a talented, experienced, and growing team of dedicated individuals
• 401(k) plan with employer matching for contributions
• Stock options
• Excellent medical, dental, and vision coverage
• Open, flexible vacation policy
• Support to attend professional conferences that are meaningful to your career growth
• Monthly cell phone and internet stipend
• Wellness benefits and access to onsite fitness center
• Commuter benefits
• Salary Range : $120,000-$160,000