Company Description
Zymeworks is a publicly listed (NASDAQ:ZYME) R&D and clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates. We are  a global company headquartered in Vancouver, BC, with operations in Bellevue, WA, Dublin, Ireland, Singapore and Redwood City, CA. 

Why Work With Us

Nothing is more critical to our success than the quality of our team. The work we do is meaningful and impactful - we care about each other as well as the patients we serve. We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

This role will be located in Vancouver, BC and is hybrid with a minimum of 3 days per week onsite. 

How You'll Contribute

We are seeking a Principal Scientist, Immunology to advance novel biologic therapeutics for Th2-associated autoimmune diseases. Key responsibilities include overseeing the entire lifecycle of projects, from conceptualization to IND submission. This role involves working with and leading a team of researchers, providing scientific and organizational guidance, mentorship, and talent development. The Principal Scientist will stay abreast of cutting-edge developments in immunology, therapeutic modalities, and competitive landscapes, fostering a culture of continuous learning and expertise expansion. The ideal candidate holds a PhD with 8-10 years of relevant experience, demonstrating a strong track record of scientific innovation, particularly in Th2-associated biology. Effective communication, leadership, and problem-solving skills are essential, along with the ability to thrive in a collaborative, high-achieving environment.  

What You'll Do

• Work with and direct a talented team of Immunology researchers to deliver an innovative and sustainable pipeline in Immunology, across a diversity of modalities, from inception through IND in autoimmune diseases.
• Support development of immunology portfolio strategy and attainment of departmental scientific and pipeline goals and through managing research, people and resources.
• In collaboration with R&D PMO, coordinates cross-departmental activities to ensure strategic alignment, resource efficiency and timely delivery.
• Supports the evaluation and review of project plan and data.
• Keep up to date with latest development in immunology (e.g. T cell, macrophage and NK biology, etc.), therapeutic modalities (e.g. multi-functional biologics, cytokines etc.), and competitive landscape.
• Support the expansion of expertise and knowledge in Immunology research and biologic drug development within the department and across the discovery organization.
• Provide day-to-day scientific and organizational direction and support for the department. Mentors and develops talent, providing performance feedback, training opportunities, and exposure to new assignments.

What You'll Bring

• PhD with 8-10 years of directly relevant research experience in immune oncology and/or immunology, or an equivalent combination of education and experience.
• Proven track record of scientific innovation and accomplishment as evidenced by publications, patents, and conference presentations. 
• Deep research expertise and extensive working experience in Th2-associated biology.
• Relevant biologic drug discovery experience from target discovery to IND.
• Well informed in Th2-associated autoimmune diseases, treatment landscape and therapeutic research/development trends.
• Excellent communication and interpersonal skills are required. 
• Strong motivation, attention to detail, and ability to think independently and fully integrate into a high achieving team environment.
• Strong management and leadership skills and the ability to mentor and develop strong contributors. 
• Ability to address complex scientific problems with practical research plan and efficiently execute and deliver.
• Ability to work independently and effectively on multiple programs and also collaboratively and productively in a dynamic team environment.
• A self-starter with strong scientific curiosity, creativity, and rigor, excellent analytic skills and high ethical standards.

Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. We regularly benchmark our compensation against leading biotechnology companies in our geographies. 

The base salary range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position in the location for which the job is posted and does not include bonus, equity, or benefits. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate’s location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience).

Our total rewards package that includes: 

• Industry leading vacation and paid time off
• Exceptional medical, dental and vision benefits by country
• Zymelife health and wellness benefits
• Matching RRSP / 401K / Penion program
• Employee Share Purchase Program
• Employee Equity Program
• Paid time off to volunteer in your community

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.

NOTE TO AGENCIES:  Zymeworks values our relationships with our recruiting partners.  We only accept resumes from those partners who have been contracted with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.